Brandeis University Rabb Graduate School
Office of Continuing Studies
Deanne Taylor PhD

Program Director, Bioinformatics Graduate Program

Education:

PhD in Biophysics (2001) University of Michigan, Ann Arbor MI
BA in Astronomy and Physics (1995) Wellesley College, Wellesley MA
AA in General Studies, Honors (1991) North Shore Community College, Lynn MA

Contact

dtaylor[atsign]brandeis.edu
Current Research Interests

  • Systems Biology
    Comparison of known signaling networks in tissues and cell cultures using whole-genome expression profiling.

  • Cancer/Stem Cell expression profiling and mechanisms of metastasis
    Several studies have shown that the epithelial-to-mesenchymal transition is important in tumorigenesis. I am currently comparing and contrasting gene expression profiles of human mesenchymal and cancer tissues.

  • Genomic evolution in speciation and cancer growth and selection
    In nature, genomic diversity provides a landscape on which natural selection can act to establish dominant genotypes. It is hypothesized that cancer cells evolve in a similar but much faster manner, based on a ability to adapt and survive first within a primary tumor and then in distant metastasis sites. The genomic differences which typify closely-related species reflect changes that may accrue over the span of many generations. Similarly, cancer cells may undergo similar types of genomic changes that are observed between species, such as gene duplication (amplification), point mutation, recombination, ploidy, and inversion. Can the process of cancer cell evolution provide clues as to the mechanisms operating on species genomes over evolutionary time?

  • Mechanisms of biological system evolution
    How do whole systems adapt and change, and what kind of genomic changes can we observe across closely related species?

    • Publications

    Peter Warren, Deanne Taylor, Paolo G. V. Martini, Jennifer Jackson, and Jadwiga Bienkowska, "PANP - a New Method of Gene Detection on Oligonucleotide Expression Arrays" Accepted to BIBE07 [Submitted Manuscript] [PANP website]

    Marco Muda, Chaomei He, Paolo G.V. Martini, Tania Ferraro, Sharon Layfield, Deanne Taylor, Colette Chevrier, Rene Schweickhardt, Christie Kelton , Peter L. Ryan, and Ross A.D. Bathgate. "Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity" (2005) Mol. Hum. Reprod. 11: 591-600 [PDF] [Cover image PDF]

    D.M. Taylor and A. Ramamoorthy, "Coherence Transfer Through Homonuclear Dipolar Coupling in an Unoriented Two Spin-1/2 Solid-State System."   J Mol Struct 602-603 115-124 (2002)[PDF]

    J. R. Brender, D. M. Taylor, and A. Ramamoorthy. "Orientation of Amide-Nitrogen-15 Chemical Shift Tensors in Peptides: A Quantum Chemical Study." J Am Chem Soc, 123 914-922 (2001) [PDF]

    D.M. Taylor and A. Ramamoorthy, "Analysis of Dipolar-Coupling Mediated Coherence Transfer in a Homonuclear Two-Spin-1/2 Solid-State System."   J Mag Reson 141 18-28 (1999) [PDF]

    Dissertation

    Deanne Marie Taylor, "Nuclear Magnetic Resonance Coherence Transfer in a Homonuclear Two Spin-1/2 Solid-State System." Biophysics Graduate Program, University of Michigan 2001.

    Broken up into PDF files for ease of use (big files):

    Interesting Links

    Talk Origins

    Computational Biology/Biophysics/Bioinformatics/Evolution at McMaster Univeristy

    EvolDir at McMaster University

    Felsenstein Lab at U Washington

    Barabasi Lab at Notre Dame

    Introduction to Sequence Analysis