Studies of the packing of cocrystals of alkynoic acids
with amine and pyridine acceptors
We have been successful in generating and determining the crystal
structure of a new type of carboxylic acid cocrystal with a
pyridine-based acceptor. In order to extend our work on the
solid-state reactivity and crystal engineering of pyridine- or amine :
carboxylic acid cocrystals, it seemed worthwhile to attempt to
generate two-dimensional layer structures with van der Waals
spacings between the layers. We decided to use an "extended" planar
acceptor, viz., trans-1,2-bis(4-pyridyl)ethylene 1, with
the expectation that the extended conjugation would promote the
formation of planar arrays when cocrystals were synthesized with
carboxylic acids.
We have synthesized a cocrystal with 4-pentynoic acid 2, and
have just completed an X-ray structure determination. As can be seen,
planar arrays indeed are formed!
Is this part of a bigger picture? We think so....when we synthesized
cocrystals of 1 and 2-butynoic acid, CH
C
COOH, it happened
again:
Stay tuned for further developments.
This material is based upon work supported by the National Science
Foundation under Grant No. DMR-0089257. Any opinions, findings and
conclusions or recommendations expressed in this material are those of
the authors and do not necessarily reflect the views of the National Science
Foundation (NSF).
Send content and research comments to Bruce Foxman
(
foxman1@brandeis.edu)
Bruce Foxman (
foxman1@brandeis.edu)