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Biographical Sketch

K. C. Hayes
Professor of Biology (Nutrition)

Education:

Wesleyan University, Middletown, CTB.S.1961 English, Pre-Med
Cornell University, Ithaca, New YorkD.V.M.1965 Veterinary Medicine
University of Conn., Storrs, CTPh.D.1968 Nutritional Pathology

Research and/or Professional Experience:

1968-1983 Research Fellow to Associate Professor of Nutrition, Harvard School of Public Health
1978-1982 Chairman, Nutrition Division, New England Regional Primate Research Center, Harvard Medical School
1978-1983 Lecturer in Pathology, Harvard Medical School
1983-1999 Lecturer in Nutrition, Harvard School of Public Health
1983-current Professor of Biology (Nutrition) and Director, Foster Biomedical Research Laboratory and Animal Resources, Brandeis University
1987-1990 Chairman, Department of Biology, Brandeis University

Membership on Service Advisory Committees and Boards:

1974-1978 Nutrition Study Section, N.I.H.
1976-1978 Subcommittee - Care and Use of Nonhuman Primates, ILAR, NRC-NAS
1976-1979 Council of the Institute of Laboratory Animal Care
1977-1988 American Association for Accreditation of Laboratory Animal Care
1978-1980 Committee on Nonhuman Primates, ILAR, NRC-NAS
1981-1984 Subcommittee - Nutrient Requirements of the Dog, NRC-NAS
1983-1986 Editorial Board, J. Nutrition
1983-1992 Editorial Board, Am.J.Clin.Nutr.
1984-1986 Subcommittee - Nutrient Requirements of the Cat, NRC-NAS
1984-1990 U.S.D.A. Human Nutrition Board of Scientific Counselors
1990 Charter Diplomate, American College Veterinary Nutrition
1985-1991 Tufts - U.S.D.A. Human Nutrition Center on Aging, Advisory Council
1999-2001 Publications Management Committee, Am. Soc. Nutr. Sci.
1999-2002 Editorial Board, J.Nutrition
2003- Contributing Editor, Nutrition Reviews

Memberships
American Society of Nutritional Sciences...since 1969
American Society of Clinical Nutrition...since 1969
American Heart Association (Council on Arteriosclerosis)...since 1970
International Atherosclerosis Society (IAS)...since 1978
American Oil Chemististís Society..since 1984
International Society for Study of Fatty Acids and Lipids (ISSFAL)...since 1994

Dr. Hayes is the author or co-author of more than 185 reports, 24 chapters, and 177 abstracts, the following of which are the most recent. He is co-inventor on 9 patents, and several discoveries in his lab currently have marketplace applications, eg. discovery of a taurine requirement for cats and infant primates led to taurine inclusion in all cat foods and human infant formulas. ALPO cat food originated from research in his lab, and currently most supermarkets in the USA carry SMART BALANCE, a trans fat-free margarine designed to improve the LDL/HDL ratio.

Khosla, P., Hajri, T., Pronczuk, A. and Hayes, K.C. Decreasing dietary lauric and myristic acids improves plasma lipids more favorably than decreasing dietary palmitic acid in rhesus monkeys fed AHA Step1 diets. J. Nutr. 127:525s-530s, 1997.

Sundram, K., Ismail, A., Hayes, K.C., Jeyamalar, R., and Pathmanathan, R. Trans (elaidic) fatty acids adversely affect the lipoprotein profile relative to specific saturated fatty acids in humans. J. Nutr. 127:514s-520s. 1997.

Khosla, P., Hajri, T., Pronczuk, A. and Hayes, K.C. Replacing dietary palmitic acid with elaidic acid (t-18:1?9) depresses HDL and increases CETP activity in cebus monkeys. J. Nutr. 127:531s-536s, 1997.

Hayes, K.C.The linoleic acid content of test diets must be carefully monitored in cholesterol studies. Am. J. Clin.Nutr. 65:1087-88, 1997 (letter).

Cathcart, E.S., Gonnerman, W.A., Bryant, R.E., Hajri, T., Hayes, K.C. Dietary modulation of apolipoprotein serum amyloid A (apoSAA) metabolism and prevention of amyloidosis in aging C57BL/6J and SJL/J mice. J.Nutr.Biochem.8:328-333., 1997.

Labat, J.B., Martini, M.C., Carr, T.P., Elhard, B.M., Olson, B.A., Bergman, S.D., Slavin, J.L. Hayes, K.C. and Hassel, C.A. Cholesterol-lowering effects of modified animal fat in postmenopausal women. J.Am.Coll. Nutr. 16:570-77,1997.

Khosla, P., Hajri, T., Pronczuk, A. and Hayes, K.C. Dietary oleic and palmitic acid exert similar effects on plasma lipids and lipoprotein metabolism in hamsters fed purified diets with low cholesterol but different quantities of fat. Asia Pac. J.Clin. Nutr. 6:26-30, 1997.

Hajri, T., Khosla, P., Pronczuk, A. and Hayes, K.C. Myristic acid-rich fat raises plasma LDL by stimulating LDL production without affecting fractional clearance in gerbils fed a cholesterol-free diet. J. Nutr. 128:477-484, 1998.

Hajri, T., Pronczuk, P., and Hayes. Linoleic acid-rich diet increases the activity of cholesterol 7a-hydroxylase and alters bile acid composition and conjugation in gerbils . J.Nutr. Biochem. 9:249-257,1998.

Hayes, K.C., Lindsey, S., Pronczuk, A., Trautwein, E., and Khosla, P. Fatty acid modulation of lipoprotein metabolism by natural triglycerides in hamsters: lipoprotein turnover and hepatic mRNA abundance. In, Structurally Modified Food Fats: Synthesis, Biochemistry, and Use. ed. by A. Christophe, pp.170-181. AOCS Press, 1998.

Li, T., Sandberg, M.A., Pawlyk, B.S., Hayes, K.C., Dryja, T.P., and Berson, E.L. Vitamin A supplement slows photoreceptor degeneration in mice with T17M rhodopsin mutation. Proc. Natl. Acad. Sci. 95:11933-38,1998

Hajri, T., Hayes, K.C., Sipe, J., Liang, J.S., Elliot-Bryant, R., and Cathcart, E.S. The acute phase response in apolipoprotein A-1 knock-out mice: lipid and apoSAA transport in plasma high density lipoproteins. Biochim. Biophys. Acta 1394: 209-218, 1998.

Sibulesky, L., Hayes, K.C., Pronczuk, A., Weigel-DiFranco, C., Rosner, B., L. Berson, E.L. Safety of less than 25,000 IU/day of vitamin A in young adults with retinitis pigmentosa. Am. J. Clin. Nutr. 69:656-663, 1999.

Trautwein, E.A., A. Siddiqui, and K.C. Hayes. Characterization of the bile acid profile in developing male and female hamsters in response to dietary cholesterol challenge. Comp. Biochem. Physiol. A124:93-103,1999.

Hayes KC. Medium-chain triglycerides may not raise cholesterol. Am J Clin Nutr 72:1583-84, 2000.

Hayes KC. Dietary fatty acids, cholesterol, and the lipoprotein profile. Br J Nutr.84:397-9, 2000.

Hayes KC. Synthetic and modified glycerides:effects on plasma lipids. Curr Opin Lipidol 12: 55-60,2001

Hayes, K.C. n6 versus n3 fatty acid modulation of lipoprotein metabolism. In, Omega-3 Fatty Acids: chemistry, nutrition, and health effects", ed. F. Shahidi and J.W. Finley. Am Chem. Soc., Oxford Univ Press.p,37-53,2001

Hayes, K.C., Pronczuk, A., and Perlman, D. Vitamin E in fortified cow milk uniquely enriches human plasma lipoproteins. Am J Clin Nutr. 74:211-218, 2001.

Hayes, K.C., Pronczuk, A., Wijendran, V., and Beer, M. Free phytosterols effectively reduce plasma and liver cholesterol in gerbils fed cholesterol. J Nutr 132: 1983-1988,2002.

Treadwell, R.M., Pronczuk, A., and Hayes, K.C. Glvceride stearic acid content and structure affect energy available for growth in rats J Nutr 132:3356-3362,2002.

Sher, J., Pronczuk, A., Hajri, T., and Hayes, K.C. Dietary conjugated linoleic acid (CLA) lowers plasma of the acute phase cholesterol during cholesterol supplementation, but accentuates the atherogenic lipid profile response in hamsters. J Nutr 133:456-460, 2003.

Berger,A., Monnard, I., Dionisi, F., Gumy, D., Hayes, K.C., and Lambelet, P. Cholesterol-lowering properties of amaranth flakes, crude and refined oils in hamsters. Food Chem 81 :119-124, 2003

Hayes,KC, Pronczuk, A., Cook, MW., and Robbins, MC. Betaine is nontoxic in subacute and subchronic rat studies. Food Chem Tox 41: 1685-1700,2003

Wijendran, V., Pronczuk, A., Bertoli, C., and Hayes, K.C. Dietary trans-18:1 raises plasma triglycerides and VLDL cholesterol when replacing either 16:0 or 18:0 in gerbils. J Nutr Biochem 14: 584-590, 2003

Wijendran, V, and Hayes, KC Dietary n6 and n3 Fatty Acid balance and cardiovascular health. Ann Rev Nutr 24: 597-615,2004

Hayes,KC, Pronczuk, A, and Perlman, D. Nonesterified phtytosterols dissolved and recrystalized in oil reduce plasma cholesterol in gerbils and humans. J Jutr 134: 1395-1399,2004

Berson EL, Rosner B, Sandberg MA, Weigel-DiFranco C, Moser A, Brockhurst RJ, Hayes KC, Johnson CA, Anderson EJ, Gaudio AR, Willett WC, Schaefer EJ. Clinical trial of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment. Arch Ophth. 122:1297-1305,2004

Berson EL, Rosner B, Sandberg MA, Weigel-DiFranco C, Moser A, Brockhurst RJ, Hayes KC, Johnson CA, Anderson EJ, Gaudio AR, Willett WC, Schaefer EJ. Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment: subgroup analyses. Arch Ophth. 122: 1306-14,2004.

Hayes KC. Relative cardiovascular benefits of n6 and n3 fatty acids. Nutrition and the MD 31: 1-4,2005

Hayes KC, Pronczuk A, Wijendran V, Beer M. Free phytosterols facilitate excretion of endogenous cholesterol in gerbils. J Nutr Biochem. 16:305-11,2005