The Krauss Research Group

  1. Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase

    Matos, J. O.; Kumar, R. P.; Ma, A. C.; Patterson, M.; Krauss, I. J.; Oprian, D. D. Biochemistry ASAP
  2. The Impact of Sustained Immunization Regimens on the Antibody Response to Oligomannose Glycans

    Nguyen, D. N.; Redman, R. L.; Horiya, S.; Bailey, J. K.; Xu, B.; Stanfield, R. L.; Temme, J. S.; Labranche, C. C.; Wang, S.; Rodal, A. A.; Montefiori, D. C.; Wilson, I. A.; Krauss, I. J. ACS Chem. Biol. 2020 15, 789-798.
  3. Direct Evidence of an Enzyme-Generated LPP Intermediate in (+)-Limonene Synthase Using a Fluorinated GPP Substrate Analog

    Morehouse, B. R.; Kumar, R. P.; Matos, J. O.; Yu, Q.; Bannister, A.; Malik, K.; Temme, J. S.; Krauss, I. J.; Oprian, D. D. ACS Chem. Biol. 2019 14, 2035-2043.
  4. Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities

    Nguyen, D. N.; Xu, B.; Stanfield, R. L.; Bailey, J. K.; Horiya, S.; Temme, S. J.; Leon, D. R.; LaBranche, C. C.; Montefiori, D. C.; Costello, C. E.; Wilson, I. A.; Krauss, I. J.ACS Cent. Sci. 2019, 5, 237-249.
  5. Stereoselective Homocrotylation of Aldehydes: Enantioselective Synthesis of Allylic-Substituted Z/E-Alkenes

    Tian, L; Krauss, I. J.Org. Lett. 2018 , 20, 6730-6735.
  6. Structural Characterization of Early Michaelis Complexes in the Reaction Catalyzed by (+)-Limonene Synthase from Citrus sinensis Using Fluorinated Substrate Analogues

    Kumar, R. P.; Morehouse, B. R.; Matos, J. O.; Malik, K.; Lin, H.; Krauss, I. J.; Oprian, D. D. Biochemistry 2018 , 56, 1716-1725.
  7. Directed Evolution of Glycopeptides Using mRNA Display

    Horiya, S; Bailey, J. K.; Krauss, I. J. Methods Enzymol. 2017 , 597, 83-141.
  8. DNA display of folded RNA libraries enabling RNA-SELEX without reverse transcription

    MacPherson, I. S.; Temme, J. S.; Krauss, I. J. Chem. Comm. 2017 , 53(19), 2878-2881.
  9. Synthesis of Multivalent Glycopeptide Conjugates that Mimic an HIV Epitope

    Bailey, J. K.; Nguyen, D. N.; Horiya, S.; Krauss, I. J. Tetrahedron 2016 , 72(40), 6091-6098.
  10. Antibody Recognition of HIV and Dengue Glycoproteins

    Krauss, I. J. Glycobiology 2016 , 26(8), 813-819.
  11. Enantioselective syn and anti Homocrotylation of Aldehydes: Application to the Formal Synthesis of Spongidepsin

    Lin, H. K.; Tian, L.; Krauss, I. J. J. Am. Chem. Soc. 2015 , 137(40), 13176-13182.
  12. SELMA: Selection with Modified Aptamers

    Temme, J. S.; Krauss I. J. Curr. Protoc. Chem. Biol. 2015 , 7, 73-92.
  13. Recent Strategies Targeting HIV Glycans in Vaccine Design

    Horiya, S.; MacPherson, I. S.; Krauss I. J. Nat. Chem. Biol. 2014 ,10, 990-999.
  14. Boron Carboxylate Catalysis of Homoallylboration

    Dugas, G. J.; Lam, Y.-H.; Houk, K. N.; Krauss, I. J. J. Org. Chem. 2014 ,79(10), 4277-4284. (Featured Article)
  15. Directed Evolution of Multivalent Glycopeptides Tightly Recognized by HIV Antibody 2G12

    Horiya, S.; Bailey, J. K.; Temme, S. J.; Guillen-Schlippe, Y. V.; Krauss, I. J. J. Am. Chem. Soc. 2014 , 136(14), 5407-5415. (Highlighted in C&E News, 3/31/2014) Access the recommendation on F1000Prime
  16. High Temperature SELMA: Evolution of DNA-Supported Oligomannose Clusters Which Are Tightly Recognized by HIV bnAb 2G12

    Temme, S. J.; MacPherson, I. S.; DeCourcey, J. F.; Krauss, I. J. J. Am. Chem. Soc. 2014 , 136(5), 1726-1729. Access the recommendation on F1000Prime
  17. Directed Evolution of 2G12-Targeted Nonamannose Glycoclusters by SELMA

    Temme, J. S.; Drzyzga, M.; MacPherson, I. S.; Krauss, I. J. Chem. - Eur. J. 2013 , 19(51), 17291-17295.
  18. Enantioselective Homocrotylboration of Aliphatic Aldehydes

    Lin, H.; Pei, W.; Wang, H.; Houk, K. N.; Krauss, I. J. J. Am. Chem. Soc. 2013, 135(1), 82-85. (Highlighted in Synfacts 2013, 9, 315). (Highlighted Organic Synthesis Highlights, 2/2014)
  19. Homoallylboration and Homocrotylboration of Aldehydes

    Pei, W.; Krauss, I. J J. Am. Chem. Soc. 2011, 133(46), 18514-18517. (Highlighted in Synfacts 2012, 8, 203).
  20. Multivalent Glycocluster Design Through Directed Evolution

    MacPherson, I. S.; Temme. J. S.; Habeshian, S.; Felczak, K.; Pankiewicz, K.; Hedstrom, L.; Krauss, I. J Angew. Chem. Int. Ed. 2011, 50(47), 11238-11242. Access the recommendation on F1000Prime
  21. A Short Asymmetric Route to the Bromophycolide A and D Skeleton

    Lin, H.; Pochapsky, S.S.; Krauss, I. J Org. Lett. 2011, 13(5), 1222-1225.
  22. Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative

    Gao, Y.; Kuang, Y.; Guo, Z-F.; Guo, Z.; Krauss, I. J.; Xu, Bing J. Am. Chem. Soc. 2009, 131(38), 13576-13577.
  23. Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims

    Nagorny, P.; Krauss, I. J. Njardarson, J. T.; Perez, L.; Gaul, C.; Yang, G.; Ouerfelli, O.; Danishefsky, S. J. Tetrahedron Lett. 2010, 51(30), 3873-3875.
  24. Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog

    Oskarsson, T.; Nagorny, P.; Krauss, I. J.; Perez, L.; Mandal, M.; Yang, G.; Ouerfelli, O.; Xiao, D.; Moore, M. S.; Massague, J.; Danishefskhy, S. J. J. Am. Chem. Soc. 2010, 132(9), 3224-3228.
  25. A New Model for the Presentation of Tumor-Associated Antigens and the Quest for an Anticancer Vaccine: A Solution to the Synthesis Challenge via Ring-Closing Metathesis

    Jeon, I.; Lee, D.; Krauss, I. J.; Danishefsky, S. J. J. Am. Chem. Soc. 2009, 131(40), 14337-14344.
  26. An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions

    Joyce, J. G.; Krauss, I. J.; Song, H. C.; Opalka, D. W.; Grimm, K. M.; Nahas, D. D.; Esser, M. T.; Hrin, R.; Feng, M.; Dudkin, V. Y.; Chastain, M.; Shiver, J. W.; Danishefsky, S. J. Proc. Natl. Acad. Sci. USA 2008, 105(41), 15684-15689.
  27. Total Synthesis of Spirotenuipesines A and B

    Dai, M.; Krauss, I. J.; Danishefsky, S. J. J. Org. Chem. 2008, 73(24), 9576-9583.
  28. Fully Synthetic Carbohydrate HIV Antigens Designed on the Logic of the 2G12 Antibody

    Krauss, I. J.; Joyce, J. G.; Finnefrock, A. C.; Song, H. C.; Dudkin, V. Y.; Geng, X.; Warren, J. D.; Chastain, M.; Shiver, J. W.; Danishefsky, S. J. J. Am. Chem. Soc. 2007, 129(36), 11042-11044.
  29. Total synthesis of (+)-isomigrastatin

    Krauss, I. J.; Mandal, M.; Danishefsky, S. J. Angew. Chem. Int. Ed. 2007, 46(29), 5576-5579.
  30. Highly Practical and Enantioselective Cu-Catalyzed Conjugate Addition of Alkylzinc Reagents to Cyclic Enones at Ambient Temperature

    Krauss, I. J.; Leighton, J. L. Org. Lett. 2003, 5(18), 3201-3203.
  31. Highly Regioselective and Diastereoselective Directed Hydroformylation of Allylic Ethers: A New Approach to Propionate Aldol Synthesis

    Krauss, I. J; Wang, C. C-Y.; Leighton, J. L. J. Am. Chem. Soc. 2000, 123(46), 11514-11515.