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Besides being applied directly to barrier methods of contraception, spermicide, mostly in the form of non-oxynol 9, also comes in other highly concentrated forms. People who are allergic to spermicide should not use these products. It is important to remember that these are only methods of contraception and do not protect against any STIs by themselves. Besides abstinence, the most effective method of contraception and protection from STIs is the use of a barrier method in addition to one of the following back-up methods. Some of these methods require time inside the body before they become effective, but other forms of foreplay can continue during this time.

Vaginal Contraceptive Film, or VCF, is a high concentration of spermicide in the form of a thin, square film. To use VCF, fold the film in half twice, so it is in quarters in a smaller square. Fold down the corners since they may be slightly sharp, and insert the VCF in the vagina as far as possible, preferably resting against the cervix, at the top of the vagina. There, the film will melt and coat the cervix and vaginal walls with spermicide. VCF must be inserted at least 15 minutes and no more than 45 minutes before intercourse. If the VCF starts irritating the user, remove immediately.

Contraceptive foams, such as Delfen, contain a high concentration of spermicide. To use them, first thoroughly shake the can. Place the applicator on the tip of the nozzle and push/tilt the nozzle gently. The foam will quickly fill the applicator. Insert the applicator in the vagina and push the foam into the vagina. The foam will cling to the walls of the vagina and the cervix. The foam should be inserted no more than 10-15 minutes before intercourse, because it will melt out of the body. More foam should be re-inserted before each act of intercourse.

Spermicidal jelly, sold under the brand name Gynol II, is another form of concentrated spermicide. It is most commonly used with diaphragms and cervical caps, but can also be used with condoms. While it is effective to apply spermicidal jelly to condoms, which are not already treated with spermicide, it is better to simply use condoms with spermicidal lubricant already applied to the condom.

Contraceptive inserts, sold under the brand name Concepterol, are another method of using highly concentrated spermicide for contraception. Each insert is approximately a half-inch long and less than a quarter inch in diameter. The insert should be inserted as far up in the vagina as possible. Wait ten minutes after insertion before intercourse to assure that the insert has dissolved.